Fixed jets are non adjustable but the needles with knobs are meant to be adjustable. That’s why they are on the front of the motor for easy access.
Some motors which are hard to start like having the needles richened up a bit to get them going and then they are fine tuned as the motor warms up. Altitude, air density, as on a hot or cold day and moisture in the air can all affect how a motor runs, requiring slight adjustments of the needles.