The very short answer I have is, "I don’t know." I will tell you this, though….There will probably be SOMETHING different. It may be as important as that the base design is different, to something as small as the hole for the starter is off by an eight inch. Carb mounting flanges are a biggie, to possibly be different. You will generally find much less success swapping around parts on Mercs, than you do with OMCs. The only real way to know for sure, without laboriously looking at both blocks side by side, is to do a part number search. If the original Mark 55 part number happens to superseded to the 1960 300 (which IS entirely possible but not likely) then you’re good to go. If needed, I have some old Parts Price History books that are good with tracking supersessions. I also have the "Where used record," which is sometimes helpful but not as much as the history, when doing what you’re trying to do.
Long live American manufacturing!